IMMUNOLOGY2024™ Conference Recordings-Multi-omic immunophenotyping to identify predictors of mRNA vaccine responsiveness in immunocompromised individuals

Multi-omic immunophenotyping to identify predictors of mRNA vaccine responsiveness in immunocompromised individuals

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Researchers at Oxford studied why immunocompromised people respond poorly to mRNA COVID-19 vaccines. Using the UK Octave Duo cohort, they analyzed blood from patients with varied conditions before and after a third vaccine dose with bulk RNA sequencing, proteomics, flow cytometry, and single-cell RNA-seq. They found shared inflammatory immune signatures across diseases, especially involving monocytes, and these signatures predicted weaker antibody and T-cell responses. Non-responders showed higher inflammatory monocyte gene activity before and after vaccination. The findings suggest blood-based immune profiles could help predict vaccine responsiveness in immunocompromised individuals.

Keywords

immunocompromised

mRNA COVID-19 vaccines

inflammatory monocytes

immune signatures

vaccine responsiveness