IMMUNOLOGY2025™ Conference Recordings-Antigen avidity drives the durability of the vaccine immune response

Antigen avidity drives the durability of the vaccine immune response

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Video Summary

The speaker describes a study on how antigen avidity affects vaccine durability using an HIV germline-targeting mouse model. By varying nanoparticle valency, the team found that higher avidity improved germinal center seeding, memory B-cell formation, and long-lived plasma cell responses. Higher valency also increased response diversity, while somatic hypermutation rates were similar across groups. Lower-valency effects were partly rescued when interclonal competition was reduced, suggesting competition helps shape these outcomes. Overall, antigen avidity emerged as a key driver of durable and productive vaccine-induced immunity.

Keywords

antigen avidity

HIV germline-targeting

nanoparticle valency

germinal center response

memory B-cell formation