IMMUNOLOGY2025™ Conference Recordings-Endothelial CD130 controls the phenotype and function of high endothelial venules

Endothelial CD130 controls the phenotype and function of high endothelial venules

Video Transcription

Video Summary

The speaker described a study of endothelial CD130 signaling in high endothelial venules (HEVs), specialized blood vessels that enable lymphocytes to enter lymph nodes and other lymphoid tissues. Using a new endothelial atlas across 20 mouse tissues, the team found CD130 highly enriched in venule endothelial cells alongside ACKR1. Endothelial-specific CD130 knockout mice lost HEV structures in lymph nodes, showed reduced HEV gene expression, and had major defects in T- and B-cell homing to peripheral lymph nodes, mesenteric lymph nodes, and Peyer’s patches, with no effect on the spleen. Inducible deletion after birth produced similar results, showing CD130 is required for HEV maintenance. The researchers also identified LEAF-R and oncostatin R as contributing receptors, while finding the effect was independent of the lymphotoxin beta receptor pathway. Finally, CD130 was also required for HEV formation in tumor-associated tertiary lymphoid structures.

Keywords

CD130 signaling

high endothelial venules

lymphocyte homing

endothelial knockout

tertiary lymphoid structures