IMMUNOLOGY2025™ Conference Recordings-IL-18 receptor signaling regulates IL-17A expression in lung innate lymphoid cells during fungal allergen exposure

IL-18 receptor signaling regulates IL-17A expression in lung innate lymphoid cells during fungal allergen exposure - Yung-An Huang

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Video Summary

The speaker studied how IL-18 signaling affects lung innate lymphoid cells (ILCs) during fungal allergen exposure in mice. After Alternaria challenge, IL-18 increased rapidly in the lung, and ILCs, especially ILC2s, expressed IL-18 receptors. Mice lacking IL-18 receptor showed worse allergic inflammation and greater lung cell infiltration. Although IL-5-producing ILCs were unchanged, IL-17A-producing ILCs increased, suggesting that IL-18 normally restrains ILC2s from shifting toward a type 3-like, IL-17A-producing phenotype. The findings point to IL-18 as a potential regulator and therapeutic target in fungal allergen-induced lung disease.

Keywords

IL-18 signaling

lung innate lymphoid cells

Alternaria allergen

ILC2 and IL-17A

fungal allergic inflammation