IMMUNOLOGY2025™ Conference Recordings-PEP-R619W distinctly modulates persistent type-I interferon signaling to enhance DC and CD8+ T cell function

PEP-R619W distinctly modulates persistent type-I interferon signaling to enhance DC and CD8+ T cell function

Video Transcription

Video Summary

The speaker studied the autoimmune-associated PTPN22 mutation PEP R619W and its effects on type I interferon signaling in immune cells. In naive CD8 T cells, the mutation reduced pSTAT1 and ISG expression, while increasing the negative regulator SOCS3. In dendritic cells, it enhanced pSTAT1 and ISG induction, also linked to lower SOCS3. Effector CD8 T cells retained ISG responses, and CD4 T cells showed no change. The mutation also promoted epitope-specific CD8 T cell function during chronic LCMV infection, helping clear virus. Overall, PEP R619W acts as a cell type-specific regulator of antiviral immunity.

Keywords

PTPN22

PEP R619W

type I interferon signaling

CD8 T cells

dendritic cells