IMMUNOLOGY2025™ Conference Recordings-Stk11-loss in lung adenocarcinoma is associated with an expansion of gd T cells with pro-tumor and immunosuppressive potential

Stk11-loss in lung adenocarcinoma is associated with an expansion of gd T cells with pro-tumor and immunosuppressive potential

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Video Summary

The speaker described research on gamma-delta T cells in a KRAS-driven lung adenocarcinoma mouse model with STK11 loss. STK11 deletion accelerated tumor growth and shortened survival, while increasing immunosuppressive cells like MDSCs and Tregs. Gamma-delta T cells expanded early and were mainly IL-17-producing, pro-tumor gamma-delta T17 cells. Single-cell sequencing revealed transcriptional heterogeneity, including a distinct Vγ6 subset enriched for amphiregulin, IL-2RA, PD1, and CXCL2, and a selectively activated Vγ4 subset with evidence of clonal expansion. These findings suggest tumor-specific regulation of gamma-delta T17 cells contributes to lung cancer progression.

Keywords

gamma-delta T cells

KRAS-driven lung adenocarcinoma

STK11 loss

gamma-delta T17 cells

single-cell sequencing