IMMUNOLOGY2026™ Conference Recordings For Attendees-A critical role of epithelial MHCII in initiation of autoimmune tumorigenesis and sustaining premalignancy growth in the stomach.

A critical role of epithelial MHCII in initiation of autoimmune tumorigenesis and sustaining premalignancy growth in the stomach.

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Video Summary

Clary Lozano presented research showing that epithelial MHC-II, not just immune-cell MHC-II, is crucial for autoimmunity-driven gastric tumor initiation. Using a CTLA-4 knockdown mouse model that develops gastric inflammation, metaplasia, and eventually adenocarcinoma, her lab found increased epithelial MHC-II/PD-L1 expression during disease progression. When MHC-II was removed from non-hematopoietic gastric cells, premalignancy failed to develop, and restoring MHC-II only in bone marrow-derived cells did not rescue it. She also showed that functional antigen presentation was required, since H2DM-deficient mice lacked premalignant pathology. Deleting epithelial MHC-II even after premalignancy had begun reversed disease features. Human gastric adenocarcinoma samples also showed higher EpCAM+ MHC-II+ epithelial cells. Overall, epithelial MHC-II may be a biomarker and therapeutic target in early autoimmune gastric cancer development.

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Date April 16, 2026 1:30 PM - 1:45 PM

Room 153AB

Session Antigen Presentation in Immunity, Pathology, and Tolerance

Speaker Clarisel Lozano

Track Classical and Non-Classical Antigen Presenting Cells (APC)

Year 2026

Keywords

epithelial MHC-II

gastric tumor initiation

autoimmunity

CTLA-4 knockdown mouse model

gastric adenocarcinoma

April 16, 2026 1:30 PM - 1:45 PM

153AB

Antigen Presentation in Immunity, Pathology, and Tolerance

Clarisel Lozano

Classical and Non-Classical Antigen Presenting Cells (APC)

2026