IMMUNOLOGY2026™ Conference Recordings For Attendees-A distal transcribed enhancer of KRAS fine-tunes Tfh-mediated vaccine response

A distal transcribed enhancer of KRAS fine-tunes Tfh-mediated vaccine response

Video Transcription

Video Summary

The speaker described a project mapping enhancer RNAs in human adaptive immune cells using ATAC-seq, H3K27ac ChIP-seq, and RNA-seq, identifying about 2,100 bidirectionally transcribed enhancers. They focused on a conserved enhancer RNA near KRAS, called eKRAS, and showed it acts in cis to boost KRAS expression. Deleting eKRAS in mice impaired T follicular helper (Tfh) cell signaling, reduced NF-kB/AP1 phosphorylation, weakened viral responses, and disrupted antibody class switching after influenza infection and mRNA vaccination. Human vaccine data also linked KRAS expression with Tfh signatures and antibody titers.

Meta Tag

Date April 16, 2026 10:00 AM - 10:15 AM

Room 153AB

Session Epigenetics and Post-Transcriptional Regulation

Speaker Dhaneshwar Kumar

Track Immune Response Regulation: Molecular Mechanisms (IRM)

Year 2026

Keywords

enhancer RNA

KRAS

T follicular helper cells

NF-kB/AP1 signaling

antibody class switching

April 16, 2026 10:00 AM - 10:15 AM

153AB

Epigenetics and Post-Transcriptional Regulation

Dhaneshwar Kumar

Immune Response Regulation: Molecular Mechanisms (IRM)

2026