IMMUNOLOGY2026™ Conference Recordings For Attendees-A multilevel logic for antigen interpretation governs tissue-specific T cell responses

A multilevel logic for antigen interpretation governs tissue-specific T cell responses

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Video Summary

Nicole from the Wong Lab at MIT studies how different tissues encode tissue-specific T-cell decisions balancing inflammation and tolerance. Using 25-plex IBEX imaging in lymph nodes draining various organs, she found a hierarchical logic: dendritic cells carry most tissue-specific variation, regulatory T cells next, and T cells least. Principal component analysis suggested distinct mucosal, skin, lung, and gut biases. Interstitial fluid analysis showed cytokine and chemokine patterns matched these regional differences. Treg depletion triggered stronger effector T-cell commitment in mucosal lymph nodes, indicating these sites are primed for inflammation.

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Date April 19, 2026 8:39 AM - 8:52 AM

Room 102

Session Development of Statistical, Machine Learning, and Genetic Models

Speaker Nicole Pagane

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

tissue-specific T-cell decisions

IBEX imaging

dendritic cells

regulatory T cells

mucosal lymph nodes

April 19, 2026 8:39 AM - 8:52 AM

102

Development of Statistical, Machine Learning, and Genetic Models

Nicole Pagane

Computational and Systems Immunology (COMP)

2026