IMMUNOLOGY2026™ Conference Recordings For Attendees-A single cell and spatially resolved atlas of the intestinal innate immune response to infection

A single cell and spatially resolved atlas of the intestinal innate immune response to infection

Video Transcription

Video Summary

The speaker introduced GutPath, a single-cell atlas of the mouse ileum during diverse infections, built from more than 500,000 cells using RNA and surface protein profiling. The atlas reveals 91 cell states across epithelial, stromal, immune, and nervous system lineages and is available online as a community resource. A key finding was a Yersinia pseudotuberculosis-induced enterocyte state enriched for antibacterial and STAT3-related genes. Spatial transcriptomics linked these enterocytes to pyrogranulomas, with IL-18, IL-22, and phosphorylated STAT3 signaling suggesting a localized immune response. Future work will expand to adaptive immunity, resolution, and enterocyte metabolism.

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Date April 18, 2026 1:15 PM - 1:30 PM

Room 153C

Session Emerging Topics in Mucosal Immunology

Speaker Andrew Hart

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

GutPath

mouse ileum

single-cell atlas

Yersinia pseudotuberculosis

STAT3 enterocyte state

April 18, 2026 1:15 PM - 1:30 PM

153C

Emerging Topics in Mucosal Immunology

Andrew Hart

Mucosal And Regional Immunology (MUC)

2026