IMMUNOLOGY2026™ Conference Recordings For Attendees-ATF3 Regulates Cholesterol Trafficking in Macrophages

ATF3 Regulates Cholesterol Trafficking in Macrophages

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Video Summary

The talk examines how dyslipidemia creates a lipid-rich, inflammatory environment that affects macrophages and promotes disease. It focuses on ATF3, a stress-induced transcription factor, as a coordinator of inflammation and cholesterol metabolism. In ATF3-deficient macrophages, cholesterol-handling genes and SR-BP2-target genes are blunted, yet cholesterol and IL-6 accumulation increase, suggesting defective cholesterol trafficking and persistent inflammation. The speaker proposes roles for CH25H/25HC and AsterB in trapping SR-BP2 in the ER. In vivo, ATF3 loss in liver macrophages worsens steatohepatitis and liver damage, indicating ATF3 may protect against foam cell formation and liver inflammation.

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Date April 17, 2026 8:00 AM - 8:15 AM

Room 156

Session Mechanisms of Innate Immunity

Speaker Amelia Pearson

Track Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

Year 2026

Keywords

dyslipidemia

ATF3

macrophages

cholesterol metabolism

steatohepatitis

April 17, 2026 8:00 AM - 8:15 AM

156

Mechanisms of Innate Immunity

Amelia Pearson

Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

2026