IMMUNOLOGY2026™ Conference Recordings For Attendees-Acetyl-CoA generation by Acly distinctly regulates CD4 T cell programming during Plasmodium infection

Acetyl-CoA generation by Acly distinctly regulates CD4 T cell programming during Plasmodium infection

Video Transcription

Video Summary

The speaker studied how ACLY, an enzyme that produces acetyl-CoA, affects CD4 T-cell responses during malaria. In a mouse Plasmodium model, deleting ACLY did not change Th1 cells but reduced TFH cells. Despite fewer TFHs, mice cleared infection on time and showed higher parasite burden at peak infection. ACLY-deficient TFHs had more CD40 ligand and less ICOS, suggesting altered function rather than simple loss of help. The work suggests ACLY supports malaria-specific TFH programming and may be dispensable for differentiation but important for optimal function and immune protection.

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Date April 18, 2026 1:00 PM - 1:15 PM

Room 104AB

Session Regulating Adaptive Responses

Speaker Regina Antonetti

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

ACLY

CD4 T-cell responses

malaria

TFH cells

Plasmodium model

April 18, 2026 1:00 PM - 1:15 PM

104AB

Regulating Adaptive Responses

Regina Antonetti

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026