IMMUNOLOGY2026™ Conference Recordings For Attendees-Adaptive immune responses to mirror antigens

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Video Summary

The speaker reviewed what is known about immune responses to mirror-image (D-amino acid) antigens. These molecules are highly resistant to proteolysis, which may prevent generation of peptides for MHC II presentation and weaken CD4 T-cell help. Most historical data come from older studies that may have had L-amino acid contamination. Published work generally shows poor or absent T-cell and antibody responses to mirror peptides or proteins, though some low-level responses may reflect T-independent B-cell activation or contamination. Overall, mirror proteins seem unlikely to induce strong, durable adaptive immunity, and no robust antibody responses to complex mirror proteins have been reported.

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Date April 16, 2026 12:45 PM - 2:15 PM

Room 153C

Session Immune responses to mirror molecules and organisms, Sponsored by the Mirror Biology Dialogues Fund (MBDF)

Speaker Christopher Stamper

Track Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

Year 2026

Keywords

mirror-image antigens

D-amino acid proteins

immune response

MHC II presentation

adaptive immunity

April 16, 2026 12:45 PM - 2:15 PM

153C

Immune responses to mirror molecules and organisms, Sponsored by the Mirror Biology Dialogues Fund (MBDF)

Christopher Stamper

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

2026