IMMUNOLOGY2026™ Conference Recordings For Attendees-Adrenergic Signalling Drives Accumulation of Myeloid-derived Suppressor Cells in the Liver During Stress

Adrenergic Signalling Drives Accumulation of Myeloid-derived Suppressor Cells in the Liver During Stress

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Video Summary

A PhD student presented research showing that prolonged psychological stress rapidly drives a large accumulation of myeloid-derived suppressor cells (MDSCs) in the mouse liver. These cells were identified as PMN-like MDSCs based on surface markers, nuclear morphology, and their ability to suppress T cell proliferation. Stress increased serum cytokines such as IL-6 and G-CSF; blocking both receptors prevented MDSC buildup. The effect was not mediated by the glucocorticoid/HPA axis, but by adrenergic signaling through the sympathetic-adrenal-medullary axis. The study suggests stress alters immunity by recruiting suppressive myeloid cells to the liver.

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Date April 18, 2026 1:45 PM - 2:00 PM

Room 253

Session Peripheral & Central Neuroimmune Interactions

Speaker Agetha Mahendran

Track Neuroimmunology (NEUR)

Year 2026

Keywords

psychological stress

myeloid-derived suppressor cells

mouse liver

IL-6 and G-CSF

adrenergic signaling

April 18, 2026 1:45 PM - 2:00 PM

253

Peripheral & Central Neuroimmune Interactions

Agetha Mahendran

Neuroimmunology (NEUR)

2026