IMMUNOLOGY2026™ Conference Recordings For Attendees-Aging-Associated Nrf2 Loss in Microglia Exacerbates Neuroinflammation and Trained Immunity

Aging-Associated Nrf2 Loss in Microglia Exacerbates Neuroinflammation and Trained Immunity

Video Transcription

Video Summary

The talk showed that aging reduces Nrf2 in microglia, which shifts them from a homeostatic state to a primed, disease-associated phenotype. This loss of Nrf2 increased inflammatory markers, reduced antioxidant genes, and impaired cognition in mice. Microglia-specific Nrf2 deletion also amplified trained immunity responses to LPS, with higher TNF-α and IL-1β and lower IL-10, indicating stronger immune memory and chronic neuroinflammation. Overall, the study suggests Nrf2 is a key protective regulator during aging and may be a therapeutic target to limit microglial overactivation and age-related cognitive decline.

Meta Tag

Date April 18, 2026 8:15 AM - 8:30 AM

Room 157

Session Neurodegenerative & Autoimmune Disorders

Speaker Jui-Hung Jimmy Yen

Track Neuroimmunology (NEUR)

Year 2026

Keywords

Nrf2

microglia

aging

neuroinflammation

cognitive decline

April 18, 2026 8:15 AM - 8:30 AM

157

Neurodegenerative & Autoimmune Disorders

Jui-Hung Jimmy Yen

Neuroimmunology (NEUR)

2026