IMMUNOLOGY2026™ Conference Recordings For Attendees-Airway B cells regulate neutrophilic inflammation via Fas:FasL pathways during respiratory Mycoplasma infection

Airway B cells regulate neutrophilic inflammation via Fas:FasL pathways during respiratory Mycoplasma infection

Video Transcription

Video Summary

The speaker describes mycoplasma pneumoniae as a serious cause of chronic, neutrophil-driven lung disease rather than just a cell culture contaminant. In mouse models, infection causes airway plugging and severe inflammation, worsened by prior exposure or vaccination. Their work suggests B cells normally restrain this neutrophilia through a direct, contact-dependent mechanism involving FAS/FASL and possibly CD18 and airway-recruited B cells. When B cells are depleted, neutrophil numbers and disease severity increase. The talk concludes that identifying the exact B-cell subset and mechanism could reveal new therapies, though the cells are still not fully characterized.

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Date April 16, 2026 1:00 PM - 1:15 PM

Room 156

Session Humoral-innate Immune Crosstalk

Speaker Arlind Mara

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

mycoplasma pneumoniae

neutrophil-driven lung disease

B cells

FAS/FASL signaling

airway inflammation

April 16, 2026 1:00 PM - 1:15 PM

156

Humoral-innate Immune Crosstalk

Arlind Mara

Immune Response Regulation: Cellular Mechanisms (IRC)

2026