IMMUNOLOGY2026™ Conference Recordings For Attendees-Allergen-specific regulatory T cells form lung resident memory capable of suppressing Th2 recall responses to allergen

Allergen-specific regulatory T cells form lung resident memory capable of suppressing Th2 recall responses to allergen

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Video Summary

The speaker described research on allergen-specific T cells in a mouse model of house dust mite–induced asthma. Using a special mouse line enriched for a dust mite-specific TCR and MHC tetramers, the team tracked allergen-specific helper T cells and regulatory T cells (Tregs) in the lung. They found that both Th2 effector cells and Tregs form lung resident memory populations that persist long-term and expand after allergen re-challenge. Parabiosis experiments showed these cells behave like bona fide tissue-resident memory cells. CXCR6 was identified as a key chemokine receptor needed for lung retention of both populations, with CCR8 playing a smaller role. Functionally, depleting Tregs increased proliferation of allergen-specific Th2 cells upon re-challenge, suggesting Tregs suppress recall allergic inflammation. The work supports a model where allergen-specific lung Tregs help limit asthma-like responses.

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Date April 17, 2026 4:15 PM - 4:30 PM

Room 205

Session Airway Hypersensitivity and Asthma

Speaker Ryan Nelson

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

allergen-specific T cells

house dust mite asthma

lung resident memory T cells

regulatory T cells

CXCR6

April 17, 2026 4:15 PM - 4:30 PM

205

Airway Hypersensitivity and Asthma

Ryan Nelson

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

2026