IMMUNOLOGY2026™ Conference Recordings For Attendees-Anatomic compartmentalization of a cytokine buffer system promotes anti-viral immune defense

Anatomic compartmentalization of a cytokine buffer system promotes anti-viral immune defense

Video Transcription

Video Summary

The speaker described how IL-6, a potent inflammatory cytokine, is tightly buffered in blood but not in lung tissue. In circulation, soluble IL-6 receptor and soluble GP130 neutralize free IL-6, preventing excessive systemic inflammation. After influenza infection in mice, lung fluid showed depleted buffer components and elevated IL-6, allowing strong local immune activation. Introducing a soluble GP130Fc “buffer” reduced IL-6 signaling, decreased immune cell recruitment, and increased viral load. The talk concluded that spatial organization of IL-6 buffering is crucial: blood suppresses runaway inflammation, while lung tissue permits protective, localized immune responses.

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Date April 18, 2026 1:21 PM - 1:33 PM

Room 153AB

Session Pathophysiology of Cytokines and Chemokines

Speaker Larance Ronsard

Track Cytokines and Chemokines and their Receptors (CCR)

Year 2026

Keywords

IL-6

inflammatory cytokine

soluble GP130Fc

influenza infection

immune response

April 18, 2026 1:21 PM - 1:33 PM

153AB

Pathophysiology of Cytokines and Chemokines

Larance Ronsard

Cytokines and Chemokines and their Receptors (CCR)

2026