IMMUNOLOGY2026™ Conference Recordings For Attendees-Antibody response to Burkholderia pseudomallei in a 13-year chronic infection: Relationship of antibody response to bacterial genomics and proteomics

Antibody response to Burkholderia pseudomallei in a 13-year chronic infection: Relationship of antibody response to bacterial genomics and proteomics

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Video Summary

The transcript covers two studies on host-pathogen immune interactions. The first examines a patient infected for 13 years with <em>Burkholderia pseudomallei</em> (melioidosis). Longitudinal isolates and serum samples showed progressive genome deletions, reduced expression of key carbohydrate antigens (LPS and capsule), and a shift in antibody responses from carbohydrate-dominated to protein-focused immunity. Despite conserved antigen genes, protein expression changed over time, suggesting immune-driven adaptation and loss of immunogenic targets.

The second study investigates mouse models carrying IRF4 or IKZF3 mutations linked to B- and T-cell defects and susceptibility to <em>Pneumocystis murina</em>. Only IRF4 homozygous mice were highly susceptible, largely because they failed to upregulate CD40 ligand on CD4 T cells. Both mutant strains still mounted lung immune responses and could migrate toward chemokines, while B-cell responses were delayed or reduced. Together, the work highlights how pathogens and immunity shape each other over chronic infection.

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Date April 17, 2026 1:30 PM - 1:45 PM

Room 153C

Session Adaptive Immune Responses to Microbial Infections

Speaker Jinhee Yi

Track Microbial, Parasitic, and Fungal Immunology (MPF)

Year 2026

Keywords

Burkholderia pseudomallei

melioidosis

immune evasion

IRF4 mutation

Pneumocystis murina

CD40 ligand

April 17, 2026 1:30 PM - 1:45 PM

153C

Adaptive Immune Responses to Microbial Infections

Jinhee Yi

Microbial, Parasitic, and Fungal Immunology (MPF)

2026