IMMUNOLOGY2026™ Conference Recordings For Attendees-Antigen Presentation by Tumor Endothelium Promotes CD8+ T Cell Recruitment

Antigen Presentation by Tumor Endothelium Promotes CD8+ T Cell Recruitment

Video Transcription

Video Summary

The talk described how tumor endothelial cells can present tumor antigens and help recruit T cells into tumors. In poorly organized, angiogenic tumors, endothelial antigen presentation was increased when angiogenesis was inhibited. The speaker showed that endothelial cells can take up antigen, load it onto MHC class I, and promote infiltration of naïve CD8 T cells through an LFA-1/ICAM-1-dependent mechanism. Loss of endothelial antigen presentation reduced CD8 T-cell infiltration and increased tumor growth in multiple mouse models. Single-cell RNA-seq suggested that endothelial antigen presentation supports stem-like, memory-like anti-tumor CD8 T cells. Finally, combining anti-angiogenic therapy with immune checkpoint blockade increased antigen-presenting endothelial cells, boosted antigen-specific CD8 T cells, and reduced tumor burden, providing a mechanistic rationale for the combination treatment.

Meta Tag

Date April 17, 2026 5:00 PM - 5:15 PM

Room 153AB

Session Cellular Responses and the Tumor Microenvironment

Speaker Yoojung Kwon

Track Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

Year 2026

Keywords

tumor endothelial cells

antigen presentation

CD8 T-cell infiltration

anti-angiogenic therapy

immune checkpoint blockade

April 17, 2026 5:00 PM - 5:15 PM

153AB

Cellular Responses and the Tumor Microenvironment

Yoojung Kwon

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

2026