IMMUNOLOGY2026™ Conference Recordings For Attendees-Antigen dependency defines memory and exhausted CD8 T cell fates

Antigen dependency defines memory and exhausted CD8 T cell fates

Video Transcription

Video Summary

Jenny presents research on whether antigen-experienced T cells still depend on antigen to survive and function. Using a new inducible P14 TCR knockout mouse, her lab found that memory T cells formed after acute infection persist without TCR signaling, though loss of TCR lowers PD-1 expression, especially in resident memory cells. In chronic infection models, however, TCR-negative cells are lost over time, showing antigen dependence on a spectrum rather than a simple yes/no distinction. The results suggest tissue-resident and exhausted T cells are shaped differently by antigen history and persistence.

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Date April 16, 2026 1:00 PM - 1:15 PM

Room 157

Session Homeostasis

Speaker Jenny Krause

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

T cell antigen dependence

P14 TCR knockout

memory T cells

PD-1 expression

chronic infection

April 16, 2026 1:00 PM - 1:15 PM

157

Homeostasis

Jenny Krause

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026