IMMUNOLOGY2026™ Conference Recordings For Attendees-Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension

Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension

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Video Summary

The speaker presented research on how hypertension may be perpetuated by kidney-resident, memory-like CD8 T cells (TRM-like cells). She showed that hypertensive human kidneys and mouse models contain increased CD8 T cells expressing TRM markers such as CD69 and CD103, especially in the kidney interstitium. Her work suggests these cells form without classical antigen exposure and instead are driven by high extracellular ATP and TGF-beta. These TRM-like cells produce interferon-gamma, interact with distal tubule cells, and promote sodium transporter upregulation, increasing sodium retention and blood pressure. In mouse models, blocking TGF-beta signaling prevented TRM-like cell formation and reduced both salt-sensitive hypertension and hypertension recurrence after angiotensin II withdrawal. Overall, the study argues that kidney TRM-like CD8 T cells help “remember” hypertension and may be a therapeutic target.

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Date April 15, 2026 3:30 PM - 3:45 PM

Room 157

Session Orchestration of the Adaptive Immune Response

Speaker Katherine Deck

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

hypertension

kidney-resident CD8 T cells

TRM-like cells

TGF-beta signaling

sodium retention

April 15, 2026 3:30 PM - 3:45 PM

157

Orchestration of the Adaptive Immune Response

Katherine Deck

Immune Mechanisms of Human Disease (HUM)

2026