IMMUNOLOGY2026™ Conference Recordings For Attendees-Antigen-presenting cell-T cell interactions shaping immune responses to intestinal antigens

Antigen-presenting cell-T cell interactions shaping immune responses to intestinal antigens

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Video Summary

The speaker described how intestinal immune cells decide whether antigens from food or microbes trigger tolerance or inflammation. Using a “lipstick” labeling system, the team tracked antigen-presenting cells (APCs) that interact with T cells. They found distinct APC subsets control responses to dietary antigens, worm infections, and gut microbes like SFB and Bacteroides. APC identity and antigen context, not just antigen sequence, determined whether T cells became Tregs or Th17 cells. A dual-color version revealed that changing the bacterial context can redirect APC presentation and T-cell fate. The work may help explain inflammatory bowel disease and guide future therapies.

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Date April 17, 2026 1:30 PM - 1:45 PM

Room 153AB

Session T Cell Responses to the Gut Microbiota

Speaker Maria Cecilia Campos Canesso

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

intestinal immune cells

antigen-presenting cells

T cell fate

tolerance and inflammation

gut microbiota

April 17, 2026 1:30 PM - 1:45 PM

153AB

T Cell Responses to the Gut Microbiota

Maria Cecilia Campos Canesso

Mucosal And Regional Immunology (MUC)

2026