IMMUNOLOGY2026™ Conference Recordings For Attendees-Antigen-specific CD8 T cells are primed in the bone marrow by migratory myeloid DCs bringing antigen from the brain following inflammatory injuries

Antigen-specific CD8 T cells are primed in the bone marrow by migratory myeloid DCs bringing antigen from the brain following inflammatory injuries

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Video Summary

Eliese Moelker showed that after brain viral or inflammatory insult, antigen-specific CD8 T cells accumulate in the bone marrow, are largely tissue-resident, and appear with similar kinetics to lymphoid tissues. Blocking T-cell circulation did not prevent their formation, indicating local priming in the bone marrow by migratory myeloid APCs carrying brain-derived antigen. These cells formed durable memory and could be reactivated weeks later. Rechallenge with cognate antigen disrupted bone marrow LSK stem cell homeostasis, an effect reduced by CD8 depletion. The work links brain inflammation to local immune priming and long-term stem cell niche disruption.

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Date April 16, 2026 2:00 PM - 2:15 PM

Room 104AB

Session CD8+ T Cell and NK Cell Mediated Antiviral Immunity

Speaker Eliese Moelker

Track Viral Immunology (VIR)

Year 2026

Keywords

bone marrow

CD8 T cells

brain inflammation

local immune priming

stem cell niche disruption

April 16, 2026 2:00 PM - 2:15 PM

104AB

CD8+ T Cell and NK Cell Mediated Antiviral Immunity

Eliese Moelker

Viral Immunology (VIR)

2026