IMMUNOLOGY2026™ Conference Recordings For Attendees-BCR Density Regulates IgE Germinal Center B Cell Survival

BCR Density Regulates IgE Germinal Center B Cell Survival

Video Transcription

Video Summary

The project investigated how IgE B-cell receptor density affects germinal center survival and differentiation. Using CRISPR, the team deleted IgE’s secreted polyadenylation site, creating “IgE SPAD” mice with higher surface IgE BCR and no secreted IgE. These mice showed fewer IgE germinal center B cells and plasma blasts. Mixed bone marrow chimeras and BCL2 experiments suggested the plasma blast defect is not due to apoptosis alone. In contrast, increased IgE BCR density reduced germinal center apoptosis, confirmed in a separate mouse model. Overall, higher BCR density improves IgE germinal center survival without changing allergic effector responses.

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Date April 18, 2026 9:45 AM - 10:00 AM

Room 151

Session Immediate Hypersensitivity

Speaker Abdulrahman Adam

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

IgE B-cell receptor density

germinal center survival

CRISPR IgE SPAD mice

plasma blast differentiation

BCL2 apoptosis

April 18, 2026 9:45 AM - 10:00 AM

151

Immediate Hypersensitivity

Abdulrahman Adam

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

2026