IMMUNOLOGY2026™ Conference Recordings For Attendees-Bivalent vaccination fails to enhance conserved spike T cell responses across BetaCoronaviruses

Bivalent vaccination fails to enhance conserved spike T cell responses across BetaCoronaviruses

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Video Summary

The speaker described efforts to develop a pan-arenavirus T cell vaccine. The team mapped human CD4 T cell epitopes across Lassa virus proteins, identified conserved T cell epitope regions (CDERs), and showed these regions are cross-reactive across multiple old-world arenaviruses. LCMV infection in humans generated memory CD4 T cells that recognized Lassa-based CDERs. They then designed AI-based mRNA-LNP vaccines using these CDERs and tested them in mice, where they induced strong, polyfunctional Th1 responses, especially from the L construct. Cross-reactivity to LCMV in mice was limited, guiding further vaccine optimization.

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Date April 16, 2026 1:00 PM - 1:15 PM

Room 102

Session Learning about Human Immune Responses from Vaccination and Immunotherapy

Speaker Ziyin Wang

Track Vaccines and Immunotherapy (VAC)

Year 2026

Keywords

pan-arenavirus vaccine

Lassa virus

CD4 T cell epitopes

mRNA-LNP vaccine

cross-reactive CDERs

April 16, 2026 1:00 PM - 1:15 PM

102

Learning about Human Immune Responses from Vaccination and Immunotherapy

Ziyin Wang

Vaccines and Immunotherapy (VAC)

2026