IMMUNOLOGY2026™ Conference Recordings For Attendees-CCL20-CCR6 signaling modifies cellular metabolism in CD4 T cells and drives the differentiation of pathogenic Th17 cells

CCL20-CCR6 signaling modifies cellular metabolism in CD4 T cells and drives the differentiation of pathogenic Th17 cells

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Video Summary

The talk explored how the chemokine receptor CCR6 and its ligand CCL20 guide T cells to inflamed tissues and also help program their inflammatory behavior. In ulcerative colitis and mouse colitis models, CCR6/CCL20 signaling increased pathogenic Th17-like cells, including Tbet/RORγt double-positive cells, while CCR6 deficiency reduced disease. RNA-seq, proteomics, and metabolic studies showed activation of PI3K-AKT-mTOR-STAT3 pathways and a shift toward glycolysis over oxidative phosphorylation. The speaker concluded that CCR6 not only directs T-cell migration but also promotes metabolic adaptation and inflammatory differentiation, making it a potential therapeutic target.

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Date April 18, 2026 12:57 PM - 1:09 PM

Room 153AB

Session Pathophysiology of Cytokines and Chemokines

Speaker Girdhari Lal

Track Cytokines and Chemokines and their Receptors (CCR)

Year 2026

Keywords

CCR6

CCL20

Th17 cells

ulcerative colitis

PI3K-AKT-mTOR-STAT3

April 18, 2026 12:57 PM - 1:09 PM

153AB

Pathophysiology of Cytokines and Chemokines

Girdhari Lal

Cytokines and Chemokines and their Receptors (CCR)

2026