IMMUNOLOGY2026™ Conference Recordings For Attendees-CD1-Mediated Lipid Antigen Presentation Orchestrates Neuroinflammation in Alzheimer's Disease

CD1-Mediated Lipid Antigen Presentation Orchestrates Neuroinflammation in Alzheimer's Disease

Video Transcription

Video Summary

The speaker, Jitika Rajpoot, presented research on how lipids contribute to neuroinflammation in Alzheimer&rsquo;s disease through CD1-mediated lipid antigen presentation. She explained that the brain is highly lipid-rich and that lipids are not only structural and energy-storage molecules but can also act as immune antigens. In Alzheimer&rsquo;s disease, microglia accumulate altered lipid droplets near amyloid plaques and become dysfunctional. Her team found that these lipid droplets are structurally and compositionally changed in disease. They also discovered that CD1D, the lipid-presenting molecule in mice, is mainly upregulated in astrocytes rather than microglia, especially in plaque-rich brain regions and as disease progresses. Reducing lipid droplets with a targeted degrader lowered plaque burden, astrocytic inflammation, and CD1D expression. The study suggests that microglial lipid droplets help shape a pro-inflammatory environment in Alzheimer&rsquo;s disease.

Meta Tag

Date April 16, 2026 1:45 PM - 2:00 PM

Room 153AB

Session Antigen Presentation in Immunity, Pathology, and Tolerance

Speaker Jitika Rajpoot

Track Classical and Non-Classical Antigen Presenting Cells (APC)

Year 2026

Keywords

Alzheimer's disease

neuroinflammation

lipid droplets

CD1-mediated antigen presentation

astrocytes

April 16, 2026 1:45 PM - 2:00 PM

153AB

Antigen Presentation in Immunity, Pathology, and Tolerance

Jitika Rajpoot

Classical and Non-Classical Antigen Presenting Cells (APC)

2026