IMMUNOLOGY2026™ Conference Recordings For Attendees-CD69 Promotes Rapid Activation of Skin-Resident Memory T Cells

CD69 Promotes Rapid Activation of Skin-Resident Memory T Cells

Video Transcription

Video Summary

Victoria Hallisey presented thesis work on CD69 in tissue-resident memory T cells (TRMs). TRMs are long-lived cells that rapidly respond to re-exposure to antigen and help protect tissues from infection, but can also contribute to autoimmunity. In her vaccinia/OVA ear model, CD69 knockout TRMs formed normally but showed reduced early inflammation after peptide re-challenge: fewer monocytes, less vascular leakage, and lower TNF-α production. These results suggest CD69 helps TRMs mount a rapid inflammatory response, possibly by promoting TNF-α release rather than controlling cell numbers. She is also testing whether deleting CD69 at the memory phase gives similar results.

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Date April 17, 2026 11:00 AM - 11:15 AM

Room 102

Session Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Speaker Victoria Hallisey

Track Cellular Adhesion, Migration, and Inflammation (CAM)

Year 2026

Keywords

CD69

tissue-resident memory T cells

TRMs

TNF-alpha

vaccinia OVA ear model

April 17, 2026 11:00 AM - 11:15 AM

102

Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Victoria Hallisey

Cellular Adhesion, Migration, and Inflammation (CAM)

2026