IMMUNOLOGY2026™ Conference Recordings For Attendees-Characterising humoral and airway immunity following Respiratory Syncytial Virus infection challenge in older adults

Characterising humoral and airway immunity following Respiratory Syncytial Virus infection challenge in older adults

Video Transcription

Video Summary

Researchers studied RSV infection in healthy adults aged 60–75 using a human challenge model and compared them with younger adults. Older volunteers tolerated infection and bronchoscopy safely, but infected older adults had much higher viral loads than younger people. Serum neutralizing antibodies rose after infection in both groups and were durable in older adults, while nasal antibody responses appeared weaker and less lasting. Lung sampling showed similar patterns. Notably, baseline nasal IgA against the RSV G protein was associated with protection from infection, suggesting G-targeted mucosal immunity may be important for future vaccine design beyond current F-protein-based vaccines.

Meta Tag

Date April 19, 2026 8:15 AM - 8:30 AM

Room 104AB

Session CD4+ T Cell and B Cell Mediated Immunity against Viruses

Speaker Pete Dayananda

Track Viral Immunology (VIR)

Year 2026

Keywords

RSV infection

older adults

human challenge model

mucosal immunity

G protein IgA

April 19, 2026 8:15 AM - 8:30 AM

104AB

CD4+ T Cell and B Cell Mediated Immunity against Viruses

Pete Dayananda

Viral Immunology (VIR)

2026