IMMUNOLOGY2026™ Conference Recordings For Attendees-Characterizing Host-Viral Interaction Interfaces for Insights into Viral Transmission and Infections

Characterizing Host-Viral Interaction Interfaces for Insights into Viral Transmission and Infections

Video Transcription

Video Summary

Researchers built a structurally resolved host-virus interactome by using AlphaFold to map residue-level interfaces across over 11,000 verified human-virus protein interactions from 33 viral families. This enabled new analyses of selection, conservation, and interface mimicry. Human interface residues showed population-specific selection signals, while viral interface residues were less conserved than non-interface residues. High-mutation viruses tended to mimic human interfaces and share binding sites, and HPV interface sharing distinguished high-risk from low-risk strains. The resource also revealed a mechanism where HSV UL37 blocks MAVS-TRAF6 binding to suppress interferon signaling. The database is publicly available for further study and collaboration.

Meta Tag

Date April 15, 2026 2:45 PM - 3:00 PM

Room 151

Session Immunological -omics Analysis

Speaker Priyamvada Guha Roy

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

AlphaFold

host-virus interactome

protein-protein interfaces

viral mimicry

interferon signaling

April 15, 2026 2:45 PM - 3:00 PM

151

Immunological -omics Analysis

Priyamvada Guha Roy

Computational and Systems Immunology (COMP)

2026