IMMUNOLOGY2026™ Conference Recordings For Attendees-Clostridioides difficile-Driven Expansion of IL1B+ Monocytes Amplifies Neutrophil Recruitment in Ulcerative Colitis

Clostridioides difficile-Driven Expansion of IL1B+ Monocytes Amplifies Neutrophil Recruitment in Ulcerative Colitis

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Video Summary

The talk examined ulcerative colitis patients colonized with toxin-negative C. difficile using single-cell RNA sequencing. Even without toxin production, C. difficile-positive mucosa showed increased monocytes, especially CXCL8- and CXCL10-expressing inflammatory monocytes, in both non-inflamed and inflamed tissue. These monocytes displayed activation, antigen presentation, migration, and neutrophil-recruitment programs, while macrophages also showed inflammatory changes. The findings suggest subclinical C. difficile colonization may prime mucosal inflammation in UC and worsen disease. Targeting CXCL8-positive monocyte recruitment could be a therapeutic strategy, though neutrophil validation and larger cohorts are needed.

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Date April 16, 2026 9:15 AM - 9:30 AM

Room 153AB

Session Microbial Pathogenesis

Speaker Eun Hye Yoon

Track Microbial, Parasitic, and Fungal Immunology (MPF)

Year 2026

Keywords

ulcerative colitis

C. difficile colonization

single-cell RNA sequencing

inflammatory monocytes

CXCL8

April 16, 2026 9:15 AM - 9:30 AM

153AB

Microbial Pathogenesis

Eun Hye Yoon

Microbial, Parasitic, and Fungal Immunology (MPF)

2026