IMMUNOLOGY2026™ Conference Recordings For Attendees-Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP

Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP

Video Transcription

Video Summary

The talk introduced Nanomap, a method for mapping alpaca nanobody repertoires with better breadth and detail. Nanobodies are easier to manufacture and sequence than conventional antibodies. Nanomap clusters related sequences to identify clonal families, then uses enrichment and competition assays to map binding, epitopes, and variant specificity. The speaker showed strong repertoire coverage and benchmarked Nanomap favorably against existing clustering methods. Applications included schistosome, botulinum toxin, and SARS-CoV-2 studies, revealing promising therapeutic candidates, new epitopes, and broadly variant-cross-reactive nanobodies.

Meta Tag

Date April 18, 2026 12:45 PM - 1:00 PM

Room 102

Session Computational Tool Development

Speaker William White

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

Nanomap

alpaca nanobodies

clonal families

epitope mapping

SARS-CoV-2

April 18, 2026 12:45 PM - 1:00 PM

102

Computational Tool Development

William White

Computational and Systems Immunology (COMP)

2026