IMMUNOLOGY2026™ Conference Recordings For Attendees-Cooperative molecular mimicry drives prolonged autoinflammation in multisystem inflammatory syndrome in children

Cooperative molecular mimicry drives prolonged autoinflammation in multisystem inflammatory syndrome in children

Video Transcription

Video Summary

The talk examined MIS-C, a rare but serious post–SARS-CoV-2 hyperinflammatory syndrome in children. Using single-cell RNA/TCR sequencing, cytokine profiling, and mass cytometry from acute, follow-up, and healthy pediatric samples, the study found that inflammation can persist for months after clinical recovery. Researchers identified expanded T cells, including TRBV11-2/Vβ21.3 populations, and evidence that many SARS-CoV-2-reactive TCRs also recognize autoantigens. Elevated autoantibodies matched several of these targets. The findings support an autoimmune component in MIS-C, with lingering autoreactive T cells and subclinical inflammatory signaling even after treatment.

Meta Tag

Date April 18, 2026 10:00 AM - 10:15 AM

Room 102

Session Animal Models and Multi-omics Technology

Speaker Haley Randolph

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

MIS-C

SARS-CoV-2

autoreactive T cells

autoantibodies

single-cell RNA sequencing

April 18, 2026 10:00 AM - 10:15 AM

102

Animal Models and Multi-omics Technology

Haley Randolph

Immune Mechanisms of Human Disease (HUM)

2026