IMMUNOLOGY2026™ Conference Recordings For Attendees-Coordinated circulating and tissue-based T cell responses precede xenograft rejection

Coordinated circulating and tissue-based T cell responses precede xenograft rejection

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Video Summary

Ekaterina Novikova presented a study on T cell responses preceding rejection of genetically modified pig kidneys transplanted into a brain-dead human recipient. Using serial kidney biopsies and blood samples, her team tracked T cell receptor clonotypes over time. They found that human CD3+ T cells infiltrated the xenograft during rejection, but a dominant memory T cell clone expanded first in blood, appeared before clinical rejection, and later matched a clonotype in the kidney. The findings suggest circulating T cells can foreshadow xenograft rejection and may help identify preexisting xenoreactive memory T cells for future patient risk stratification.

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Date April 17, 2026 4:30 PM - 4:45 PM

Room 102

Session From A to X: Next-Gen Targets & Interventions for Alloimmunity, GVHD, and Xenotransplantation

Speaker Ekaterina Novikova

Track Transplantation Immunology (TRAN)

Year 2026

Keywords

xenograft rejection

T cell receptor clonotypes

pig kidney transplant

memory T cells

xenoreactive T cells

April 17, 2026 4:30 PM - 4:45 PM

102

From A to X: Next-Gen Targets & Interventions for Alloimmunity, GVHD, and Xenotransplantation

Ekaterina Novikova

Transplantation Immunology (TRAN)

2026