IMMUNOLOGY2026™ Conference Recordings For Attendees-Critical role of 4-1BB:4-1BBL axis in humoral immune responses against Plasmodium

Critical role of 4-1BB:4-1BBL axis in humoral immune responses against Plasmodium

Video Transcription

Video Summary

Carolina Caloba discussed how the 4-1BB/4-1BB ligand axis shapes immune responses against malaria-causing Plasmodium. Using knockout mice and blocking antibodies, her team found that 4-1BB and 4-1BB ligand are important for controlling parasite burden, especially early in infection, and for generating protective memory B cell responses. They also identified galectin-9 as an additional 4-1BB-binding partner that helps coordinate effector responses. In B cells, 4-1BB ligand enhanced BCR signaling, supported germinal center and memory B cell formation, and prevented abnormal proliferation, highlighting its key role in effective antimalarial immunity.

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Date April 17, 2026 5:00 PM - 5:15 PM

Room 153C

Session Signaling Pathways Modulating Immune Responses to Microbial Infections

Speaker Carolina Caloba

Track Microbial, Parasitic, and Fungal Immunology (MPF)

Year 2026

Keywords

4-1BB

4-1BB ligand

malaria immunity

memory B cells

galectin-9

April 17, 2026 5:00 PM - 5:15 PM

153C

Signaling Pathways Modulating Immune Responses to Microbial Infections

Carolina Caloba

Microbial, Parasitic, and Fungal Immunology (MPF)

2026