IMMUNOLOGY2026™ Conference Recordings For Attendees-De novo pyrimidine synthesis controls lupus-prone germinal center B cell and plasma cell fates

De novo pyrimidine synthesis controls lupus-prone germinal center B cell and plasma cell fates

Video Transcription

Video Summary

Julia Weber discusses how de novo pyrimidine synthesis supports B-cell-driven autoimmunity in SLE. Using FcγR2B knockout mice, her lab found increased pyrimidine metabolism, especially UMP production, in autoimmune B cells. B-cell-specific deletion of UMPS reduced germinal center and plasma cell responses, ANA levels, and kidney immune damage. The knockout also lowered glycolysis, mitochondrial respiration, ATP production, and other metabolic pathways. Mechanistically, mTORC1–S6 kinase phosphorylates CAD to activate pyrimidine synthesis. Overall, the pathway appears to fuel both B-cell metabolism and lupus-like autoimmune responses.

Meta Tag

Date April 16, 2026 4:00 PM - 4:15 PM

Room 253

Session Immunometabolism in Autoimmunity

Speaker Julia Weber

Track Basic Autoimmunity (BA)

Year 2026

Keywords

de novo pyrimidine synthesis

B-cell autoimmunity

SLE lupus

UMPS

mTORC1-CAD pathway

April 16, 2026 4:00 PM - 4:15 PM

253

Immunometabolism in Autoimmunity

Julia Weber

Basic Autoimmunity (BA)

2026