IMMUNOLOGY2026™ Conference Recordings For Attendees-Derivation of Mesenchymal Stem Cells from Induced Pluripotent Stem Cells and Their Application in Genetic Disease Modeling

Derivation of Mesenchymal Stem Cells from Induced Pluripotent Stem Cells and Their Application in Genetic Disease Modeling

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Video Summary

Dr. Giuseppe Sangiorgio presented an in vitro platform to model thymic stromal defects using induced pluripotent stem cells (iPSCs) differentiated into mesenchymal stem cells (MSCs). He studied patients with TBX1 mutation, trisomy 21, DiGeorge syndrome, and CHARGE syndrome, generating iPSC-derived MSCs and thymic mesenchymal cells from tissue samples. Transcriptomic analyses showed distinct cell populations and a pro-fibrotic collagen/extracellular matrix program, especially in DiGeorge syndrome. He aims to combine these MSCs with epithelial cells to build isogenic artificial thymic organoids for studying thymus biology and primary immunodeficiencies.

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Date April 15, 2026 4:15 PM - 4:30 PM

Room 153AB

Session T Cell Development

Speaker Giuseppe Sangiorgio

Track Hematopoiesis and Immune System Development (HEM)

Year 2026

Keywords

thymic stromal defects

induced pluripotent stem cells

mesenchymal stem cells

DiGeorge syndrome

artificial thymic organoids

April 15, 2026 4:15 PM - 4:30 PM

153AB

T Cell Development

Giuseppe Sangiorgio

Hematopoiesis and Immune System Development (HEM)

2026