IMMUNOLOGY2026™ Conference Recordings For Attendees-Development of T-cell-based immunotherapy against chronic Hepatitis B infection

Development of T-cell-based immunotherapy against chronic Hepatitis B infection

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Video Summary

The speaker described hepatitis B virus biology, its global burden, and why chronic infection is hard to cure. They explained that T cells are crucial for viral clearance, but chronic infection involves T cell exhaustion and liver inflammation. To study and potentially improve T cell-based immunotherapy, the lab engineered rhesus macaque hepatocytes to express the human entry receptor NTCP, enabling infection. They then identified hepatitis B–specific CD8 T cells, mapped immunogenic peptides and MHC restriction, cloned TCRs, and re-expressed them in primary T cells. This created a preclinical platform to evaluate adoptive T cell therapy and track immunity with tetramers.

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Date April 16, 2026 4:30 PM - 4:45 PM

Room 102

Session Innovations Targeting Adaptive Immune Mechanisms against Viral Pathogens

Speaker Sofiya Yusova

Track Vaccines and Immunotherapy (VAC)

Year 2026

Keywords

hepatitis B virus

T cell exhaustion

NTCP receptor

CD8 T cells

adoptive T cell therapy

April 16, 2026 4:30 PM - 4:45 PM

102

Innovations Targeting Adaptive Immune Mechanisms against Viral Pathogens

Sofiya Yusova

Vaccines and Immunotherapy (VAC)

2026