IMMUNOLOGY2026™ Conference Recordings For Attendees-Development of an in vitro Sjögren's disease tissue chip for mechanistic studies and drug screening

Development of an in vitro Sjögren's disease tissue chip for mechanistic studies and drug screening

Video Transcription

Video Summary

Chuan Chen presented research on developing an in vitro Sjogren’s disease salivary gland model for mechanistic studies and drug screening. Using the MRL/lpr mouse model, the team found increased immune infiltration, especially CD45+, CD4+, and CD8+ T cells, plus more alpha-smooth muscle actin cells, suggesting fibrosis. They created a microbubble tissue chip that maintains salivary gland cell viability and function for at least a week, unlike 2D culture. Disease-derived tissue mimetics showed reduced calcium response to carbachol, indicating impaired secretion. Future work includes deeper tissue characterization, environmental exposure studies, and screening JAK inhibitors, with potential translation to human samples.

Meta Tag

Date April 18, 2026 1:15 PM - 1:30 PM

Room 151

Session Technical Innovations for Therapies

Speaker Chiao Yun Chen

Track Technological Innovations in Immunology (TECH)

Year 2026

Keywords

Sjögren’s disease

salivary gland model

microbubble tissue chip

immune infiltration

JAK inhibitors

April 18, 2026 1:15 PM - 1:30 PM

151

Technical Innovations for Therapies

Chiao Yun Chen

Technological Innovations in Immunology (TECH)

2026