IMMUNOLOGY2026™ Conference Recordings For Attendees-Dietary Iron Overload Rewires Regulatory T Cells into IL-17-Mediated Proinflammatory Effectors Aggravating Yersinia enterocolitica Infection

Dietary Iron Overload Rewires Regulatory T Cells into IL-17-Mediated Proinflammatory Effectors Aggravating Yersinia enterocolitica Infection

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Video Summary

Researchers studied iron overload in mice fed a high-iron diet and found it greatly increased susceptibility to Yersinia enterocolitica infection. Iron overload boosted inflammatory cytokines, bacterial burden, neutrophil infiltration, and mortality. Mechanistically, it reprogrammed intestinal regulatory T cells into IL-17-producing, Th17-like cells while reducing ST2-positive, tissue-repair Tregs. These IL-17+ Tregs showed lower suppressive capacity and could drive inflammation in epithelial cells. Treating infected mice with anti-IL-17 antibodies restored Treg balance and improved survival to about 80%. The speaker suggested iron may alter Treg metabolism through glycolysis, mTOR, HIF-1α, and possibly ferroptosis.

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Date April 18, 2026 9:43 AM - 9:58 AM

Room Ballroom

Session Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Speaker Shreya Das

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

iron overload

Yersinia enterocolitica

regulatory T cells

IL-17

anti-IL-17 therapy

April 18, 2026 9:43 AM - 9:58 AM

Ballroom

Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Shreya Das

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026