IMMUNOLOGY2026™ Conference Recordings For Attendees-Dietary lipids are delivered to Tregs in chylomicrons and determine intestinal Treg survival.

Dietary lipids are delivered to Tregs in chylomicrons and determine intestinal Treg survival.

Video Transcription

Video Summary

Alexandra Cermak from the University of Pittsburgh presented research showing that intestinal Tregs take up dietary triglycerides from chylomicrons through receptors like LDLR and CD36. Using radioactive lipid tracing and mouse models, her team found that blocking chylomicron uptake preserved Treg survival, increased colonic Tregs, and protected against DSS and adoptive-transfer colitis. In contrast, wild-type chylomicrons reduced Treg viability and increased apoptosis and ROS. The study suggests that dietary lipid transport via chylomicrons can regulate intestinal Treg survival and may offer a new therapeutic target for inflammatory bowel disease.

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Date April 17, 2026 10:30 AM - 10:45 AM

Room 156

Session New Paradigms in T Cell Regulation

Speaker Alexandra Cermak

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

intestinal Tregs

chylomicrons

dietary triglycerides

colitis

inflammatory bowel disease

April 17, 2026 10:30 AM - 10:45 AM

156

New Paradigms in T Cell Regulation

Alexandra Cermak

Immune Response Regulation: Cellular Mechanisms (IRC)

2026