IMMUNOLOGY2026™ Conference Recordings For Attendees-Dissecting transcription factor networks for tissue-resident CD8 T cell differentiation and maintenance

Dissecting transcription factor networks for tissue-resident CD8 T cell differentiation and maintenance

Video Transcription

Video Summary

The speaker describes research on tissue-resident memory CD8 T cells (T_RM), which protect barrier tissues by rapidly sensing infection and activating nearby immune responses. Using CRISPR knockouts in an acute LCMV infection model, the lab tested transcription factors RUNX3, HOBIT, BLIMP1, and KLF2 across many tissues. RUNX3 mainly affected tissue retention molecules like CD103 in intestinal cells. HOBIT and BLIMP1 showed little single-knockout effect, suggesting redundancy. KLF2 strongly promoted circulation and limited residency, especially in lymphoid organs and liver. Overall, tissue environment and infection context shape T_RM fate more than any single transcription factor.

Meta Tag

Date April 16, 2026 1:45 PM - 2:00 PM

Room 157

Session Homeostasis

Speaker Courtney Matson

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

tissue-resident memory CD8 T cells

CRISPR knockout

RUNX3

KLF2

LCMV infection

April 16, 2026 1:45 PM - 2:00 PM

157

Homeostasis

Courtney Matson

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026