IMMUNOLOGY2026™ Conference Recordings For Attendees-Distinct Inflammatory Programs Underlie the Intramuscular Lipid Nanoparticle Response

Distinct Inflammatory Programs Underlie the Intramuscular Lipid Nanoparticle Response

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William Dowell presented research on how lipid nanoparticles (LNPs), used in mRNA vaccines and RNA therapeutics, can trigger different immune responses depending on their ionizable lipid chemistry. He showed that some lipids are strongly inflammatory, driving rapid neutrophil recruitment and inflammatory gene expression in muscle, while others are much less so. Using reporter mice, he found that LNPs transfect immune cells including dendritic cells, macrophages, B cells, and splenic cDC2s, which then increase activation markers such as MHC class II. His team proposed that differences in endosomal damage and repair, especially via ALIX-mediated repair, may help explain why some LNPs are inflammatory and others are not. By quantifying repair, damage, and NF-κB signaling, they aim to link LNP chemistry to immunogenicity.

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Date April 18, 2026 10:45 AM - 11:00 AM

Room 157

Session Mechanistic Insights into Determinants of Vaccine Immunogenicity

Speaker Will Dowell

Track Vaccines and Immunotherapy (VAC)

Year 2026

Keywords

lipid nanoparticles

mRNA vaccines

immune response

endosomal damage

NF-kB signaling

April 18, 2026 10:45 AM - 11:00 AM

157

Mechanistic Insights into Determinants of Vaccine Immunogenicity

Will Dowell

Vaccines and Immunotherapy (VAC)

2026