IMMUNOLOGY2026™ Conference Recordings For Attendees-E3 Ubiquitin Ligase Peli1 Regulates TLR7-Driven Spontaneous Germinal Center and Plasma Cell Development

E3 Ubiquitin Ligase Peli1 Regulates TLR7-Driven Spontaneous Germinal Center and Plasma Cell Development

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Video Summary

The speaker studied how the E3 ligase Peli-1 affects TLR7-driven lupus-like B-cell responses. In lupus models, loss of Peli-1 increased TLR7 expression, germinal center formation, plasma cells, autoantibodies, ANA positivity, and B-cell metabolism. B-cell-specific knockout showed these effects were intrinsic to B cells, without major T-cell changes. RNA-seq and validation experiments suggested Peli-1 suppresses NFAT5 downstream of TLR7. Overall, Peli-1 acts as a brake on autoimmune B-cell activation and may be a potential therapeutic target in lupus.

Meta Tag

Date April 17, 2026 1:45 PM - 2:00 PM

Room Ballroom

Session Inflammatory Mechanisms in Systemic Autoimmunity

Speaker Tien Bui

Track Basic Autoimmunity (BA)

Year 2026

Keywords

Peli-1

TLR7

lupus-like B-cell responses

NFAT5

autoimmune B-cell activation

April 17, 2026 1:45 PM - 2:00 PM

Ballroom

Inflammatory Mechanisms in Systemic Autoimmunity

Tien Bui

Basic Autoimmunity (BA)

2026