IMMUNOLOGY2026™ Conference Recordings For Attendees-Engineered probiotics limit T-cell driven CNS autoimmunity by activating AHR-KLF4-FADS3 signaling in intestinal dendritic cells

Engineered probiotics limit T-cell driven CNS autoimmunity by activating AHR-KLF4-FADS3 signaling in intestinal dendritic cells

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Video Summary

Carolina Polonio presented research showing that the aryl hydrocarbon receptor (AHR) in dendritic cells restrains CNS inflammation in multiple sclerosis models. In EAE and MS patient samples, AHR, along with CALFOR and FADS3, drives DHA production, which promotes tolerogenic dendritic cells and reduces pathogenic Th1/Th17 responses. Deleting any component worsened disease. The team then engineered probiotic bacteria to produce indole-3-acetic acid, an AHR ligand, which activated this pathway via oral gavage, lowered neuroinflammation, and reduced harmful T-cell migration from gut to CNS. Future work will test this strategy in progressive disease models.

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Date April 18, 2026 8:00 AM - 8:15 AM

Room 157

Session Neurodegenerative & Autoimmune Disorders

Speaker Carolina Polonio

Track Neuroimmunology (NEUR)

Year 2026

Keywords

aryl hydrocarbon receptor

dendritic cells

multiple sclerosis

DHA production

probiotic bacteria

April 18, 2026 8:00 AM - 8:15 AM

157

Neurodegenerative & Autoimmune Disorders

Carolina Polonio

Neuroimmunology (NEUR)

2026