IMMUNOLOGY2026™ Conference Recordings For Attendees-Epitope-Specific Neutralizing IgG4 Antibodies Define Natural and Acquired Tolerance in Peanut Allergy

Epitope-Specific Neutralizing IgG4 Antibodies Define Natural and Acquired Tolerance in Peanut Allergy

Video Transcription

Video Summary

The speaker described research showing that specific “neutralizing” peanut-specific IgG4 antibodies are linked to natural tolerance and sustained tolerance after oral immunotherapy. By isolating and mapping antibodies from children and adults, the team identified conformational epitopes on Ara h 2 and found that certain IgG4 antibodies strongly block IgE binding and allergic activity, outperforming non-neutralizing antibodies in ELISA and mouse models. These neutralizing antibodies were enriched in people with higher peanut reactivity thresholds and in sustained responders after therapy, suggesting they may serve as biomarkers of clinical tolerance and potential targets for improving allergy treatments.

Meta Tag

Date April 18, 2026 10:15 AM - 10:30 AM

Room 151

Session Immediate Hypersensitivity

Speaker Tarun Keswani

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

peanut allergy

IgG4 antibodies

oral immunotherapy

Ara h 2 epitopes

clinical tolerance

April 18, 2026 10:15 AM - 10:30 AM

151

Immediate Hypersensitivity

Tarun Keswani

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

2026