IMMUNOLOGY2026™ Conference Recordings For Attendees-Extracellular cAMP as a potent immune modulator promotes T cell exhaustion in chronic lymphocytic leukemia

Extracellular cAMP as a potent immune modulator promotes T cell exhaustion in chronic lymphocytic leukemia

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The speaker discussed how extracellular cyclic AMP contributes to T cell exhaustion in chronic lymphocytic leukemia (CLL). Unlike solid tumors, CLL cells circulate throughout the body and appear to secrete cyclic AMP into the plasma. Elevated plasma cyclic AMP was found in CLL patients, correlated with Rai stage, and helped distinguish patients from healthy controls with high specificity. In vitro, extracellular cyclic AMP reduced T cell cytokine production and proliferation, increased exhaustion markers such as PD-1 and CD160, and lowered activation scores. Single-cell and bulk analyses showed that cyclic AMP also altered monocytes and reduced naive T cells and Tregs. Overall, the findings suggest that CLL cells release cyclic AMP as an immunomodulatory metabolite that promotes immune dysfunction and T cell exhaustion, potentially contributing to disease progression.

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Date April 18, 2026 12:45 PM - 1:00 PM

Room 205

Session Molecular Mechanisms of Tumor Immunity

Speaker Shokrollah Elahi

Track Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

Year 2026

Keywords

chronic lymphocytic leukemia

cyclic AMP

T cell exhaustion

immune dysfunction

PD-1

April 18, 2026 12:45 PM - 1:00 PM

205

Molecular Mechanisms of Tumor Immunity

Shokrollah Elahi

Tumor Immunology: Checkpoints, Prevention, And Treatment (TIPT)

2026