IMMUNOLOGY2026™ Conference Recordings For Attendees-Fractalkine/CX3CL1 Functions as a Transmembrane Receptor to Promote Transendothelial Migration through glycan-dependent condensation

Fractalkine/CX3CL1 Functions as a Transmembrane Receptor to Promote Transendothelial Migration through glycan-dependent condensation

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Video Summary

The speaker presented research on fractalkine, a membrane-bound chemokine, showing it can act as a signaling molecule during leukocyte transmigration across endothelial cells. Using endothelial cell assays, they found fractalkine overexpression promotes monocyte migration, while knockout reduces it. They showed its mucin-like stalk domain and glycosylation, especially sialic acid, are essential for forming membrane condensates through electrostatic interactions. These condensates recruit and activate VEGFR2, which is required for fractalkine-driven transmigration. The talk suggests glycan modification can control membrane-protein signaling and may be influenced by shear stress and possibly siglecs.

Meta Tag

Date April 18, 2026 12:45 PM - 12:57 PM

Room 153AB

Session Pathophysiology of Cytokines and Chemokines

Speaker KAZUKI SATO

Track Cytokines and Chemokines and their Receptors (CCR)

Year 2026

Keywords

fractalkine

leukocyte transmigration

endothelial cells

glycosylation

VEGFR2

April 18, 2026 12:45 PM - 12:57 PM

153AB

Pathophysiology of Cytokines and Chemokines

KAZUKI SATO

Cytokines and Chemokines and their Receptors (CCR)

2026