IMMUNOLOGY2026™ Conference Recordings For Attendees-From CRISPR Perturbation Screens Towards Consilient Model-Informed Principles for CAR T-Cell Design

From CRISPR Perturbation Screens Towards Consilient Model-Informed Principles for CAR T-Cell Design

Video Transcription

Video Summary

The speaker discussed why CAR T-cell therapies often fail: many patients don’t achieve durable control because the cells don’t persist long enough and can become exhausted. To address this, the team is developing high-throughput screening strategies targeting either CAR design or the T-cell regulome. They introduced Consilience, a single-cell multi-omics platform that learns regulatory cell-state dynamics and predicts how perturbations affect transitions. They also described ConBind, which designs guide RNAs for cis-regulatory element editing. Early pilot results show modest agreement with experiments, but the approach is promising for improving CAR T persistence, with future screens focused on cis-regulatory elements.

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Date April 19, 2026 8:26 AM - 8:39 AM

Room 102

Session Development of Statistical, Machine Learning, and Genetic Models

Speaker Stefan Cordes

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

CAR T-cell therapy

T-cell exhaustion

single-cell multi-omics

Consilience

cis-regulatory element editing

April 19, 2026 8:26 AM - 8:39 AM

102

Development of Statistical, Machine Learning, and Genetic Models

Stefan Cordes

Computational and Systems Immunology (COMP)

2026